Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp208 | Cell biology: osteoblasts and bone formation | ECTS2013

The positional origins of human osteoblasts dictate growth and differentiation potential and capacity for paracrine vascular cell cross-talk via VEGF

Shah Mittal , Gburcik Valentina , Sankey Andrew , Reilly Peter , Emery Roger , Clarkin Claire , Pitsillides Andrew

Successful long-term, cementless fixation of human shoulder components in osteoporotic (OP) and osteoarthritic (OA) patients poses major challenges. The possibility that enhanced osseointegration may rely on both the region of bone targeted and its relationship with the vasculature remains unexplored. We hypothesise that bone cells derived from subchondral (SC), cortical (C) and trabecular (Trb) bone regions exhibit differing osteogenic potential, which will be diminished in b...